Donepezil is an oral medication used to treat alzheimer’s disease. Chemically the drug is 2,3-dihydro-5, 6-dimethoxy-2-[(1-(phenyl methyl)-4-piperidinyl) methyl]-1H-inden-1-onehydrochloride. Several methods such as HPLC, LC/MS/MS, HPLC/MS. Donepezil has been tested in other cognitive disorders including lewy body dementia and vascular dementia but it is not currently approved for these indications. Donepezil has been found to improve sleep apnea in Alzheimer’s patients. The studies found that speech of austistic children who were mild to moderately affected appeared to improve from the use of donepezil medication. Memantine HCl (MEM) which is chemically 1‐Amino‐3, 5‐dimethyltricyclo decane hydrochloride is an NMDA (Nmethyl‐D‐aspartate) receptor antagonist 3,4 used to slow or reverse the neuro‐degenerative process of alzheimer’s disease. A number of methods such as UPLC, LC‐MS were reported for the estimation of MEM. Literature survey reveals that visible spectrophotometric methods and stability studies have not been reported for its quantitative determination in combination pharmaceutical formulations. The clinical and pharmaceutical analysis of this drug requires effective analytical procedures for quality control and pharmacodynamic and pharmacokinetic studies as well as stability study. An extensive survey of the literature published in various analytical and pharmaceutical chemistry related journals has been conducted and the instrumental analytical methods which were developed and used for determination as single or combination with other drugs in bulk drugs, formulations and biological fluids have been reviewed.
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